-
Randomized Controlled Trial
Comparison of the Stress Responses Following TAP Block and Epidural Anesthesia in Patients Undergoing Elective Laparoscopic Cholecystectomy Under General Anesthesia: Randomized Clinical Trial.
- Piroozeh Taheri, Zeinab Moinfar, and Hesam A Varpaei.
- Department of Critical Care Medicine, Tehran University of Medical Sciences, Tehran, Iran.
- Clin J Pain. 2023 Jul 1; 39 (7): 319325319-325.
ObjectiveMajor surgeries and the accompanied acute stress response are associated with poor immune system function and extensive immunologic changes. This study was conducted to compare postsurgery stress responses after transversus abdominis plane (TAP) blocks and epidural anesthesia in patients undergoing laparoscopic cholecystectomy under general anesthesia.Materials And MethodsSixty patients who were candidates for laparoscopic cholecystectomy were enrolled in this randomized controlled trial. After randomly assigning patients into 2 groups (30 patients in epidural anesthesia and 30 patients in the TAP block group), the degree of pain and stress responses (serum level of blood glucose, C-reactive protein [CRP], interleukin-1, tumor necrosis factor-alpha, cortisol) of patients were measured preoperatively and at 6 and 24 hours after surgery.ResultsMean blood glucose, serum cortisol, CRP, and white blood cell decreased significantly 6 and 24 hours after the intervention in both groups and differed significantly between the 2 groups ( P -value <0.05). The proportion of patients with a pain score greater than 3 at 6 and 12 hours after surgery was significantly higher in the Epidural group compared with the TAP block group, although this figure was significantly higher in the TAP block group 24 hours after surgery.DiscussionA significant decrease in the mean blood sugar, serum cortisol, CRP, and white blood cell in both groups at 6 and 24 hours after the surgery was noted. The pain score decreased 24 hours after surgery in the epidural anesthesia group and increased in the TAP block group.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.