• Internal medicine · Dec 2023

    Case Reports

    Successful Treatment of Steroid-resistant Eosinophilic Gastrointestinal Disease with Mepolizumab: A Case Report.

    • Kentaro Ito, Tomoyoshi Shibuya, Kei Nomura, Mayuko Haraikawa, Taro Kurosawa, Keiichi Haga, Yoichi Akazawa, Takashi Murakami, Osamu Nomura, Mariko Hojo, Takashi Yao, and Akihito Nagahara.
    • Department of Gastroenterology, Juntendo University School of Medicine, Japan.
    • Intern. Med. 2023 Dec 1; 62 (23): 346134673461-3467.

    AbstractWe experienced a case of treatment-resistant eosinophilic gastrointestinal disease (EGID). The patient, a 46-year-old man, presented with a fever, persistent abdominal pain, and an elevated peripheral eosinophil count. Eosinophil infiltration of the intestinal mucosa was also observed, and EGID was diagnosed. Corticosteroid therapy was initiated, but no improvement was seen. However, after mepolizumab (anti-interleukin 5 antibody) was administered, the patient's disease was controlled. Currently, the indications for mepolizumab are limited to bronchial asthma and paraneoplastic eosinophilic polyangiitis, but the experience herein reported suggests its usefulness in the treatment of EGID.

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