• Internal medicine · Jul 2023

    Review

    Exacerbations of Idiopathic Systemic Capillary Leak Syndrome following BNT162b2 mRNA COVID-19 Vaccine (Pfizer-BioNTech).

    • Yutaro Akiyama, Takeshi Inagaki, Shinichiro Morioka, Eiji Kusano, and Norio Ohmagari.
    • Disease Control and Prevention Center, National Center for Global Health and Medicine, Japan.
    • Intern. Med. 2023 Jul 1; 62 (13): 201320172013-2017.

    AbstractA Japanese man experienced three episodes of hypovolemic shock and was diagnosed with systemic capillary leak syndrome (SCLS). He developed SCLS exacerbation 2 days after receiving a second dose of the Pfizer-BioNTech BNT162b2 mRNA COVID-19 vaccine, 1 year after the third episode. After fluid therapy and albumin administration, we initiated terbutaline and theophylline prophylaxis for SCLS. A literature review revealed that SCLS attacks often occur 1-2 days after the second COVID-19 vaccination. Patients with a history of SCLS should avoid COVID-19 vaccination and be carefully monitored for 1-2 days if they receive the vaccine.

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