• Vigdis Schnell Husby, Torbjørn Rian, Jomar Klaksvik, Tina Strømdal Wik, and Siri Bjørgen Winther.
• Department of Orthopaedic Surgery, Trondheim University Hospital, Trondheim, Norway.
• Medicine (Baltimore). 2023 Apr 21; 102 (16): e33471e33471.

BackgroundThe aim of this study was to investigate whether objectively recorded physical activity in the first week after surgery in total knee arthroplasty patients differed between patients allocated to 3 different analgesic regimens.MethodsA total of 132 total knee arthroplasty patients wore activity monitors 24 hours a day from day 1 after surgery for 6 consecutive days. The time mobilized (stepping/standing) and the number of steps were recorded. This study was a sub-study of a randomized controlled study comparing tapentadol extended-release (ER), oxycodone controlled-release (CR), or a non-opioid placebo analgesic regimen.ResultsThe placebo group spent significantly more time mobilized than the tapentadol ER and the oxycodone CR groups (P = .016 and .042, respectively), but no statistically significant differences were found between the groups in the number of steps taken. The activity levels of patients in all groups increased in the first week after surgery.ConclusionPatients in the non-opioid placebo group spent more time mobilized the first week after surgery than those in the tapentadol ER and the oxycodone CR groups, while the number of steps was not different between the groups.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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