• Amber N Edinoff, Omar H Fahmy, Noah J Spillers, Alexa R Zaheri, Eric D Jackson, Audrey J De Witt, Danielle M Wenger, Elyse M Cornett, Kimberly L Skidmore, Adam M Kaye, and Alan D Kaye.
• Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA. aedinoff@mgh.harvard.edu.
• Curr Pain Headache Rep. 2023 Jul 1; 27 (7): 175181175-181.

Purpose Of ReviewOpioid use disorder (OUD) is a chronic disorder in which a person loses control over the use of opioids, develops a compulsive behavior, and defends the use despite knowing the negative consequences. There are numerous treatments for OUD, including buprenorphine. Since it is displacing a full agonist opioid, precipitated withdrawal can occur with standard inductions involving buprenorphine.Recent FindingsCase reports have noted success with a low-dose initiation of buprenorphine, which is different from typical protocols, relatively limited by adverse effects when patients were recently administered full agonists. A cohort investigation studied the use of a transdermal patch as part of the protocol, which was fairly well tolerated. While ongoing research is being conducted on this topic, recent case studies and smaller cohort studies have demonstrated the feasibility of a trial to treat OUD with low-dose initiation of buprenorphine.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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