• Nathalie Alemán-García, José A García-García, Marco A Durán-Padilla, María E Gutiérrez-Díaz-de Ceballos, Thelma Rizo-Pica, Ana Del C Susunaga-Notario, and Celia Sánchez-Pérez.
• Institute od Applied Sciences and Technology, Universidad Nacional Autónoma de México.
• Gac Med Mex. 2023 Jan 1; 159 (2): 122128122-128.

BackgroundThe gold standard for determining the degree of liver fibrosis (LF) continues to be biopsy evaluation. There are morphometry techniques that allow LF to be quantified on histopathological studies.ObjectiveTo measure the correlation between LF histological evaluation and fibrosis percentage (FP) morphometric quantification using the HepaScan software.Material And MethodsObservational, analytical, cross-sectional, prospective, prolective pilot study in which liver histological sections from 29 people who died from some liver disease and from 22 people who died from other causes (controls) were analyzed. FP was calculated with HepaScan on digital photographs of histological sections stained with the Masson technique, comparing it with the diagnosis established by three expert pathologists.ResultsFour-hundred and one images from the group with liver disease and 250 from the control group were analyzed. Inter-observer agreement had a kappa index of 0.329. There were FP statistically significant differences (p = 0.0001) between histopathological classification groups. HepaScan predictive capacity based on the area under the receiver operating characteristic curve was 0.983, 0.812, and 0.895 for mild, moderate, and severe fibrosis, respectively.ConclusionsHepaScan showed very good performance for evaluating FP in histological sections, which is why it can contribute to qualitative pathological diagnosis.Copyright: © 2023 Permanyer.

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