• Rong Zhou, Yingying Zhang, Suhong Tang, Xiaokun Zhang, Yan Wang, Yue Liu, Xiaoping Gu, Bailing Hou, Yang Jiao, and Zhengliang Ma.
• Department of Anesthesiology, Affiliated Drum Tower Hospital, Medical School, Nanjing University, Nanjing, China.
• J. Cardiothorac. Vasc. Anesth. 2023 Aug 1; 37 (8): 143314411433-1441.

ObjectivesTo evaluate the efficacy of a single preoperative dose of S-ketamine for chronic postsurgical pain (CPSP) in patients undergoing video-assisted thoracoscopic surgical lung lesion resection (VATS).DesignA prospective randomized, double-blind controlled study.SettingPatients were enrolled from March 17, 2021, to November 18, 2021, at a single tertiary academic hospital.ParticipantsPatients were 18-to-65 years of age and undergoing VATS.InterventionsThe experiment was divided into an S-ketamine group (0.5 mg/kg intravenous injection before anesthesia induction) or a placebo group (the same volume of normal saline).Measurements And Main ResultsThe primary endpoint was the incidence of CPSP and its neuropathic component. The secondary endpoints included acute postoperative pain, the use of postoperative analgesics, anxiety and sleep quality scores, and the occurrence of adverse effects. There were no significant differences between the 2 groups in the incidences of CPSP, neuropathic pain, acute postoperative pain, and postoperative use of analgesics. The sleep quality scores on the first postoperative day differed significantly between the groups (47.45 ± 27.58 v . 52.97 ± 27.57, p = 0.049), but not the anxiety scores. In addition, adverse effects were similar between the 2 groups.ConclusionsA single preoperative dose of S-ketamine in patients who underwent VATS had no significant effect on acute and chronic postoperative pain or the consumption of analgesics after surgery. A single preoperative dose of S-ketamine could improve sleep on the first day after surgery, whereas it had no significant effect on anxiety levels.Copyright © 2023. Published by Elsevier Inc.

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