• Eur. J. Intern. Med. · Aug 2023

    Serum uric acid and left ventricular mass index independently predict cardiovascular mortality: The uric acid right for heart health (URRAH) project.

    • Maria Lorenza Muiesan, Agabiti RoseiClaudiaCDepartment of Clinical and Experimental Sciences, University of Brescia, c/o 2 Medicina - ASST Spedali Civili Brescia, Piazzale Spedali Civili 1 Brescia, Italy., Anna Paini, Edoardo Casiglia, Massimo Cirillo, Guido Grassi, Guido Iaccarino, Francesca Mallamaci, Alessandro Maloberti, Alberto Mazza, Alessandro Mengozzi, Paolo Palatini, Gianfranco Parati, Gianpaolo Reboldi, Giulia Rivasi, Elisa Russo, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Claudio Borghi, and Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA).
    • Department of Clinical and Experimental Sciences, University of Brescia, c/o 2 Medicina - ASST Spedali Civili Brescia, Piazzale Spedali Civili 1 Brescia, Italy. Electronic address: marialorenza.muiesan@unibs.it.
    • Eur. J. Intern. Med. 2023 Aug 1; 114: 586558-65.

    UnlabelledA relationship between serum uric acid (SUA) and cardiovascular (CV) events has been documented in the Uric Acid Right for Heart Health (URRAH) study.Aimof this study was to investigate the association between SUA and left ventricular mass index (LVMI) and whether SUA and LVMI or their combination may predict the incidence of CV death.MethodsSubjects with echocardiographic measurement of LVMI included in the URRAH study (n=10733) were part of this analysis. LV hypertrophy (LVH) was defined as LVMI > 95 g/m2 in women and 115 g/m2 in men.ResultsA significant association between SUA and LVMI was observed in multiple regression analysis in men: beta 0,095, F 5.47, P< 0.001 and women: beta 0,069, F 4.36, P<0.001. During follow-up 319 CV deaths occurred. Kaplan-Meier curves showed a significantly poorer survival rate in subjects with higher SUA (> 5.6 mg/dl in men and 5.1 mg/dl in women) and LVH (log-rank chi-square 298.105; P<0.0001). At multivariate Cox regression analysis in women LVH alone and the combination of higher SUA and LVH but not hyperuricemia alone, were associated with a higher risk of CV death, while in men hyperuricemia without LVH, LVH without hyperuricemia and their combination were all associated with a higher incidence of CV death.ConclusionsOur findings demonstrate that SUA is independently associated with LVMI and suggest that the combination of hyperuricemia with LVH is an independent and powerful predictor for CV death both in men and women.Copyright © 2023 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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