• Wien. Klin. Wochenschr. · May 2023

    Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients : A single center registry-based retrospective cohort study.

    • Grgur Salai, Hrvoje Vrazic, Ivona Kovacevic, Linda Malnar Janes, Ivan Marasovic, Darjan Ranilovic, Damir Vukoja, Marina Zelenika Margeta, Ivana Huljev-Sipos, Kristina Lalic, Marko Spoljaric, Jasna Tekavec-Trkanjec, Mirna Vergles, Marko Lucijanic, Ivica Luksic, and Divo Ljubicic.
    • Department of Pulmonology, University Hospital Dubrava, Zagreb, Croatia.
    • Wien. Klin. Wochenschr. 2023 May 1; 135 (9-10): 235243235-243.

    IntroductionThe impact of asthma and chronic obstructive pulmonary disease (COPD) in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) infection is not clearly defined. Blood eosinophil count is a standard diagnostic test which, according to the previously published literature, might have a potential prognostic role on mortality in patients with SARS-CoV‑2 infection.AimTo investigate the potential prognostic value of peripheral blood eosinophil count on all-cause mortality of patients hospitalized with SARS-CoV‑2 infection, as well as to assess the impact of asthma or COPD premorbidity on all-cause mortality.Material And MethodsWe conducted a retrospective registry-based cohort study. Survival analysis was performed by employing the Cox proportional hazards regression model at 30 days of follow-up. Prognostic value of eosinophil count on all-cause mortality was assessed using receiver-operating characteristic (ROC) curve analysis.ResultsA total of 5653 participants were included in the study. Our model did not reveal that pre-existing asthma or COPD is a statistically significant covariate for all-cause mortality but, indicated that higher eosinophil count at admission might have a protective effect (hazard ratio, HR 0.13 (95% confidence interval, CI 0.06-0.27), p = 0.0001). ROC curve analysis indicates cut-off value of 20 cells/mm3 (81% specificity; 30.9% sensitivity).ConclusionOur results indicate that eosinophil count at hospital admission might have a potential prognostic role for all-cause mortality at 30 days of follow-up; however this was not demonstrated for pre-existing obstructive lung diseases.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

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