• Mehrdad Mohammadpour, Mahmood Jabbarvand, Mojgan Nikdel, Mohsen Adelpour, and Nasser Karimi.
• Ophthalmology Department and Eye Research Center, Cornea Consultant, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
• J Cataract Refract Surg. 2011 Apr 1;37(4):633-7.

PurposeTo assess the prophylactic effect of preoperative application of topical diclofenac on postoperative pain control in patients having photorefractive keratectomy (PRK).SettingFarabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.DesignRandomized masked clinical trial.MethodsIn this paired-eye study, patients having bilateral PRK received 1 drop of diclofenac 0.1% in 1 eye and 1 drop of placebo in the fellow eye 2 hours before PRK. Postoperatively, both arms of the trial (both eyes of each patient) received topical diclofenac every 6 hours for 2 days. One day and 2 days postoperatively, patients were asked to rate the perceived pain in each eye using an 11-point verbal numerical rating scale. A trained examiner noted the eye-specific responses.ResultsAll 70 patients (140 eyes) completed the study and were included in the statistical analysis. Twenty-four hours after PRK, patients reported pain scores that were clinically and statistically significantly lower in the eyes pretreated with diclofenac than in the fellow eyes (0.97 versus 2.09) (P=.018). Pain scores at 2 days did not differ significantly (P=.877).ConclusionAdministration of a single drop of topical diclofenac 0.1% 2 hours before PRK seemed to increase the efficacy of postoperative pain management in a clinically and statistically significant manner.Financial DisclosureNo author has a financial or proprietary interest in any material or method mentioned.Copyright © 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

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