• J Minim Invasive Gynecol · May 2006

    Randomized Controlled Trial Comparative Study

    Topical diclofenac patch for postoperative wound pain in laparoscopic gynecologic surgery: a randomized study.

    • Franco Alessandri, Davide Lijoi, Emanuela Mistrangelo, Annamaria Nicoletti, Marco Crosa, and Nicola Ragni.
    • Department of Obstetrics and Gynaecology, San Martino Hospital and University of Genoa, Genoa, Italy.
    • J Minim Invasive Gynecol. 2006 May 1;13(3):195-200.

    Study ObjectiveTo compare pain management of standard analgesic and standard analgesic plus diclofenac transdermal patch in patients who undergo laparoscopic gynecologic surgery.DesignRandomized prospective study (Canadian Task Force classification I).SettingUniversity hospital.PatientsOne hundred twenty patients requiring laparoscopic surgery for gynecologic benign diseases.InterventionsPatients were divided into two groups, one medicated with a diclofenac patch (diclofenac group) and the other medicated with standard skin medication (placebo; control group) at all incisional areas at the end of the operation.Measurements And Main ResultsThe principal measures of outcome were pain intensity at 6, 12, and 24 hours after surgery and consumption of analgesics. The two treatment groups were comparable with respect to demographic and intraoperative characteristics. No significant difference was observed between the two groups in mean pain intensity at 6 hours after surgery. Mean pain intensity at 12 and 24 hours, respectively, after surgery was significantly lower in the diclofenac group (3.7 +/- 1.3 and 2.0 +/- 0.6) than that observed in the control group (5.7 +/- 1.9 and 4.6 +/- 0.5) (p value, respectively, .002 and <.001). Twenty-one patients (35.0%) in the diclofenac group required analgesics in the first 36 hours after the operation versus 43 patients (71.7%) in the control group (p <.001). Hospital discharge was significantly more rapid in the diclofenac group (28 +/- 5 hours vs 39 +/- 3 hours; p = .031).ConclusionDiclofenac transdermal administration seems a valid help to standard analgesic treatment in postoperative pain control and could also help reduce the period of hospitalization of patients who undergo laparoscopic benign gynecologic surgery.Copyright 2006 AAGL

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