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Review Case Reports
Severe Enteritis after Cyclophosphamide Administration in a Patient with Microscopic Polyangiitis: A Case Report and Literature Review.
- Shuhei Yoshida, Jumpei Temmoku, Tomoyuki Asano, Tsuyoshi Iwasaki, Haruki Matsumoto, Yuya Fujita, Makiko Yashiro-Furuya, Naoki Matsuoka, Naohiko Gunji, Shuzo Sato, Hiroshi Watanabe, Hiromasa Ohira, and Kiyoshi Migita.
- Department of Rheumatology, Fukushima Medical University School of Medicine, Japan.
- Intern. Med. 2023 May 1; 62 (9): 127912851279-1285.
AbstractSevere enteritis is a rare side effect of cyclophosphamide (CPA) therapy, and only two cases have been reported to date. We herein report a 60-year-old man who developed severe enteritis after intravenous CPA administration for microscopic polyangiitis. He was successfully treated by discontinuation of CPA administration and long-term intensive supportive care. A diagnosis of CPA-associated enteritis was made based on the clinical course and imaging and pathological findings. This review of three cases of CPA-related enteritis, including our case, suggests that prompt CPA discontinuation and intensive systemic management are necessary when patients have gastrointestinal symptoms after CPA administration.
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