• Internal medicine · Jan 2023

    Case Reports

    Severe Erythroderma Due to Adult-onset Still's Disease-like Disease Related to Graft-versus-host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.

    • Akiko Teramoto-Shibuya, Kaoru Funamizu, Naoki Sawa, Atsuhiko Suenaga, Yuki Oba, Daisuke Ikuma, Masayuki Yamanouchi, Eiko Hasegawa, Akinari Sekine, Tatsuya Suwabe, Kei Kono, Keiichi Kinowaki, Takeshi Fujii, Tamiko Takemura, Nobukazu Hayashi, Aya Nishida, Yuki Mori, Atsushi Wake, and Yoshifumi Ubara.
    • Department of Rheumatology and Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Japan.
    • Intern. Med. 2023 Jan 1; 62 (9): 135513591355-1359.

    AbstractA 35-year-old woman was treated with chemotherapy for leukemia. One year later, allogeneic hematopoietic stem cell transplantation (HSCT) was performed with umbilical cord blood. After nine months, she developed a spiking fever, sore throat, arthralgia, pleural effusion, hyperferritinemia, and persistent generalized pruritic erythema. A skin biopsy showed dyskeratotic cells in the epidermis, neutrophil infiltration in the epidermis and upper dermis, and neutrophils in the parakeratotic layer. Treatment with tocilizumab was effective. Adult-onset Still's disease (AOSD)-like disease related to graft versus-host disease (GVHD) after HSCT was suspected. Abnormal immune states related to GVHD may cause AOSD-like disease with more severe skin lesions than usual.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…