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Case Reports
A Case of Hepatitis C Virus-associated Cryoglobulinemic Livedo Reticularis Improved with Direct-acting Antivirals.
- Keiji Yokoyama, Tomohiro Kino, Takahiro Nagata, Takashi Miyayama, Kumiko Shibata, Hiromi Fukuda, Ryo Yamauchi, Atsushi Fukunaga, Kaoru Umeda, Kazuhide Takata, Takashi Tanaka, Satoshi Shakado, Shotaro Sakisaka, Shinichi Imafuku, and Fumihito Hirai.
- Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
- Intern. Med. 2023 Dec 15; 62 (24): 363136363631-3636.
AbstractWe herein report a case of hepatitis C virus (HCV)-associated cryoglobulinemic livedo reticularis in a woman in her 60s that improved with direct-acting antivirals (DAAs). Hyperpigmentation was observed in both lower legs, and a skin biopsy confirmed livedo reticularis, suggesting a relationship with cryoglobulinemia and HCV infection. DAAs with an NS5A inhibitor+NS3/4A protease inhibitor (glecaprevir/pibrentasvir) were administered for eight weeks, and a sustained virological response (SVR) was obtained. The disappearance of serum cryoglobulin was confirmed approximately two years after an SVR was obtained and livedo reticularis was improved. DAA therapy can be an effective therapeutic option for extrahepatic complications associated with HCV infection.
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