• Medicine · Apr 2023

    Review

    Thrombospondin-2 acts as a critical regulator of cartilage regeneration: A review.

    • Jing Niu, Yanli Liu, Junjun Wang, Hui Wang, Ying Zhao, and Min Zhang.
    • The College of Life Sciences and Medicine, Northwest University, Xi'an, P. R. China.
    • Medicine (Baltimore). 2023 Apr 25; 102 (17): e33651e33651.

    AbstractThe degeneration of articular cartilage tissue is the most common cause of articular cartilage diseases such as osteoarthritis. There are limitations in chondrocyte self-renewal and conventional treatments. During cartilage regeneration and repair, growth factors are typically used to induce cartilage differentiation in stem cells. The role of thrombospondin-2 in cartilage formation has received much attention in recent years. This paper reviews the role of thrombospondin-2 in cartilage regeneration and the important role it plays in protecting cartilage from damage caused by inflammation or trauma and in the regenerative repair of cartilage by binding to different receptors and activating different intracellular signaling pathways. These studies provide new ideas for cartilage repair in clinical settings.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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