• Kimiyo Kikuchi, Sovannary Tuot, Junko Yasuoka, Makoto Murayama, Sumiyo Okawa, Akira Shibanuma, Keiko Nanishi, Sothearith Eng, Chantheany Huot, and Siyan Yi.
• Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. kikuchi.kimiyo.715@m.kyushu-u.ac.jp.
• Bmc Med. 2023 Apr 28; 21 (1): 162162.

BackgroundMaintaining oral health is essential for improving overall health of children living with HIV. Therefore, we evaluated the effectiveness of an oral health intervention for improving their oral and overall health. In addition, we examined their longitudinal association between changes in oral and overall health.MethodsWe conducted a 2-year randomized controlled trial involving children living with HIV in Cambodia. Children aged 3-15 years and their caregivers were randomly allocated either to the intervention (group A) or control (group B) arm. A second control arm (group C) included children without HIV. The group A children received oral health education sessions and practiced home-based daily care.ResultsIn the baseline survey, 482 children participated (group A: n = 160, group B: n = 168, group C: n = 154), and 350 completed the endline survey. An interaction effect in teeth brushing duration was observed in children in group A relative to group B (AOR = 2.69, 95% CI: 1.37-5.31) and group C (AOR = 3.78, 95% CI: 1.70-8.40). Longitudinal associations were observed between changes in oral hygiene and overall health, as presented by alterations in dental caries in permanent teeth with viral load detection (adjusted odds ratio = 3.58, 95% CI: 1.10 - 11.73), in salivary flow quantity with the overall quality of life (β = 0.07, 95% CI: < 0.01 - 0.13), as well as in dental caries, salivary pH, debris index with body mass index for age among group A children.ConclusionsOral health intervention may improve oral care behaviors and potentially enhance overall health among children living with HIV in antiretroviral therapy in a resource-constrained setting.Trial RegistrationISRCTN 15177479.© 2023. The Author(s).

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