• Zhijun Zhou, Barish H Edil, and Min Li.
• Department of Medicine, The University of Oklahoma Health Sciences Center, 975 NE 10Th Street, BRC 1262A, Oklahoma City, OK, 73104, USA.
• Bmc Med. 2023 May 4; 21 (1): 171171.

BackgroundGastrointestinal cancers represent a major challenge to public health. Pancreatic cancer is the most lethal cancer among all gastrointestinal cancers. Most patients cannot meet the criteria of resection at diagnosis, indicating these patients will have dismal prognosis.Main TextNeoadjuvant chemotherapy helps some patients regain the opportunity of radical resection. An optimal regimen of chemotherapy is one that maximizes the anti-tumor efficacy while maintaining a relatively manageable safety profile. The development of surgical procedures further improves the outcomes of these patients.ConclusionsCombination therapies in a multidisciplinary manner that involves modified chemotherapy regimen, radical resection, and intestine auto-transplantation may provide the currently best possible care to patients with locally advanced pancreatic cancer.© 2023. The Author(s).

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