• Front Cardiovasc Med · Jan 2022

    Review

    Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Dysautonomia to Be Blamed?

    • Karan R Chadda, Ellen E Blakey, Christopher L-H Huang, and Kamalan Jeevaratnam.
    • Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
    • Front Cardiovasc Med. 2022 Jan 1; 9: 860198860198.

    AbstractWhile the increased arrhythmic tendency during acute COVID-19 infection is recognised, the long-term cardiac electrophysiological complications are less well known. There are a high number of patients reporting ongoing symptoms post-infection, termed long COVID. A recent hypothesis is that long COVID symptoms could be attributed to dysautonomia, defined as malfunction of the autonomic nervous system (ANS). The most prevalent cardiovascular dysautonomia amongst young people is postural orthostatic tachycardia syndrome (POTS). Numerous reports have described the development of POTS as part of long COVID. Possible underlying mechanisms, although not mutually exclusive or exhaustive, include hypovolaemia, neurotropism, inflammation and autoimmunity. Treatment options for POTS and other long COVID symptoms are currently limited. Future research studies should aim to elucidate the underlying mechanisms of dysautonomia to enable the development of targeted therapies. Furthermore, it is important to educate healthcare professionals to recognise complications and conditions arising from COVID-19, such as POTS, to allow prompt diagnosis and access to early treatment.Copyright © 2022 Chadda, Blakey, Huang and Jeevaratnam.

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    This article appears in the collection: Post-COVID POTS (Postural orthostatic tachycardia syndrome).

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