• Mehmet Yoldas, Tayfun Yoldas, İlhami Solak, Cemil Calıskan, Samed Cin, Basak Doganavsargil, Murat Sezak, Senem Alanyali, and Tuba Kuvvet Yoldas.
• Department of Urology, Tepecik Treaning and Research Hospital, Izmir-Türkiye.
• Ulus Travma Acil Cerrahi Derg. 2023 May 1; 29 (5): 547552547-552.

BackgroundThis study was designed to investigate the prophylactic and therapeutic effects of hyaluronic acid and chondroitin sulfate combination (HA/CS) on a model of acute radiation proctitis.MethodsRats were divided into five groups: SHAM; irradiation (IR) + saline (1 mL for 5th and 10th day); IR + HA/CS (1 mL for 5th and 10th day). A single fraction of 17.5 Gy was delivered to each rat. HA/CS was administered rectally each day after irradiation. Each rat was observed daily for signs of proctitis. Irradiated rats were euthanized on days 5 and 10. The mucosal changes were evaluated macroscopically and pathologically.ResultsAccording to the clinical findings, five rats in the irradiation + saline group showed grade 3-4 symptoms on the 10th day. No significant difference in the macroscopic finding scores on the 5th day was observed between the irradiation + saline and irradiation + HA/CS groups. In the pathological examination, radiation-induced mucosal damage was the most prominent finding 10 days after irradiation in saline-treated rats. On the 10th day, the irradiation + HA/CS group showed mild inflammation and slight crypt changes, which corresponded to grade 1-2 pathological findings.ConclusionWe think that HA/CS used in radiation cystitis can be beneficial for radiation proctitis.

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