• Farahnak Assadi, Anoush Azarfar, Behnaz Bazargani, Ali Derakhshan, Arash Abassi, Mehryar Mehrkash, Mastaneh Moghtaderi, Mitra Basiratnia, Mojgan Mazaheri, Afshin Safaeiasl, Alireza Eskandarifar, Fatemeh Ghane Sharbaf, Hamidreza Badeli, and Rama Naghshizadian.
• From the Division of Nephrology, Department of Pediatrics, Rush University Medical Center, Chicago IL.
• Pediatr Emerg Care. 2023 Sep 1; 39 (9): 707714707-714.

ObjectiveCurrent conventional formulas do not predict the expected changes in serum sodium after administration of various fluids to correct serum sodium abnormalities. The Adrogué-Madias formula is currently the preferred and widely used fluid prescription for adult patients with dysnatremias, but its therapeutic efficacy has not been validated in pediatric patients.MethodsIn this prospective study, we used the Adrogué-Madias formula for calculating the appropriate rate of various fluids administration to correct serum sodium abnormalities in 7 critically ill children with acute dysnatremias.ResultsAfter administration of various intravenous fluids using the Adrogué-Madias formula, the anticipated as well as the achieved sodium concentrations were almost similar.ConclusionsThis study demonstrates that the use of the Adrogué-Madias quantitative formula allows to calculate the appropriate rate of administration of various fluids. The calculated fluid administration resulted in the subsequent actual laboratory values and clinical changes.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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