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Case Reports
Nonbacterial Thrombotic Endocarditis Caused by Early-stage Lung Cancer: An Autopsy Case Report.
- Tomoaki Nagao, Atsushi Sakamoto, Mayu Fujihiro, Rika Kawakami, Kenichiro Suwa, Kazuya Hattori, Hayato Ohtani, Masao Saotome, Satoshi Baba, V FinnAlokeACVPath Institute, USA., and Yuichiro Maekawa.
- Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Japan.
- Intern. Med. 2024 Jan 1; 63 (1): 879287-92.
AbstractNonbacterial thrombotic endocarditis (NBTE) is a manifestation of prothrombotic status observed in patients with malignancy. Most cases are discovered only in the advanced stages. However, cancer in early stages may also induce NBTE development. We herein report an 87-year-old man with NBTE with multiple thromboembolization coexisting with lung cancer in early clinical stage. Autopsy findings revealed platelet- and fibrin-rich vegetations in both the tricuspid and mitral valves without evidence of bacterial infection. NBTE should be considered in cases with occult thromboembolization. Not only the presence of typical vegetation but irregular leaflet thickening should be monitored with careful echocardiographic examinations.
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