• Internal medicine · Dec 2023

    Case Reports

    Disseminated Bacillus Calmette-Guerin Infection with Rhabdomyolysis, Acute Kidney Injury, and Interstitial Pneumonia after Bacillus Calmette-Guerin Intravesical Instillation Therapy.

    • Yuki Sakurai, Yoshitaka Furuto, Takahiro Saito, Akio Namikawa, Hiroko Takahashi, and Yuko Shibuya.
    • Department of Hypertension and Nephrology, NTT Medical Centre Tokyo, Japan.
    • Intern. Med. 2023 Dec 15; 62 (24): 370737123707-3712.

    AbstractA 79-year-old man experienced a fever and immobility after receiving 6 doses of Bacillus Calmette-Guérin (BCG) intravesical instillation therapy for bladder tumor. Rhabdomyolysis and acute kidney injury occurred; therefore, hemodialysis was performed. His kidney function was restored. However, he exhibited an inflammatory reaction that was resistant to broad-spectrum antibiotics and eventually developed interstitial pneumonia. Corticosteroid treatment partially relieved the symptoms of interstitial pneumonia, although disuse syndrome persisted. He was diagnosed with disseminated BCG infection through sputum culture. BCG infection shows various symptoms and is difficult to diagnose microbiologically. It should be suspected when systemic symptoms occur after BCG intravesical instillation therapy.

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