• D S Bordin, I N Voynovan, A S Sarsenbaeva, O V Zaytsev, R A Abdulkhakov, N V Bakulina, I G Bakulin, M F Osipenko, M A Livzan, S A Alekseenko, L V Tarasova, G N Tarasova, P O Bogomolov, I V Maev, D N Andreev, S R Abdulkhakov, B D Starostin, N V Bakanova, A G Kononova, S V Kolbasnikov, E L Bueverova, L Moreira, F Megraud, C O'Morain, O Perez Nyssen, and J Gisbert.
• Loginov Moscow Clinical Scientific Center.
• Terapevt Arkh. 2023 Mar 30; 95 (2): 120129120-129.

BackgroundFirst-line therapy does not always provide a high level of Helicobacter pylori eradication due to the increase of H. pylori resistance to antibiotics; therefore, it remains necessary to identify the most effective rescue treatments. The purpose of this study was to evaluate the efficacy and safety of empirical H. pylori furazolidone-containing regimens.Materials And MethodsAdult H. pylori infected patients empirically treated with furazolidone-containing eradication regimens were registered in an international, prospective, multicenter non-intervention European registry on H. pylori management (Hp-EuReg). Data were collected at AEG-REDCap e-CRF from 2013 to 2021 and the quality was reviewed. Modified intention-to-treat (mITT) effectiveness analyses were performed.ResultsOverall 106 patients received empirical furazolidone-containing therapy in Russia. Furazolidone was prescribed in a sequential scheme along with amoxicillin, clarithromycin and a proton pump inhibitor in 68 (64%) cases, triple regimens were prescribed in 28 (26%) patients and quadruple regimens in 10 (9.4%). Treatment duration of 7 days was assigned to 2 (1.9%) patients, 10-day eradication therapy in case of 80 (75%) and 14 days - in 24 (23%) patients. Furazolidone was mainly used in first- (79%) and second-line (21%) regimens. The methods used to diagnose H. pylori infection were: histology (81%), stool antigen test (64%), 13C-urea breath test (6.6%), and rapid urease test (1.9%). The mITT effectiveness of sequential therapy was 100%; 93% with the triple therapy and 75.5% with quadruple therapy. Compliance was reported in 98% of cases. Adverse events were revealed in 5.7% of patients, mostly nausea (3.8%). No serious adverse events were reported.ConclusionFurazolidone containing eradication regimens appear to be an effective and safe empirical therapy in Russia.

27 keywords...

hide…