• I A Sadulaeva, E N Yushchuk, L F Khalikova, O V Krikunova, O S Trofimenko, and E G Medvedeva.
• Yevdokimov Moscow State University of Medicine and Dentistry.
• Terapevt Arkh. 2023 Jan 16; 94 (12): 136713731367-1373.

AimTo investigate the possibility of preclinical detection of liver damage in patients with hypertension and obesity.Materials And MethodsThe study included 168 patients with hypertension aged 30 to 60 years. All patients underwent general clinical and laboratory-instrumental examination, including ultrasound of the abdominal organs with Doppler assessment of blood flow and determination of markers such as ALT, AST, TG, lipid profile indicators at inclusion, after a month, three months and nine months.ResultsDepending on the presence of obesity, all patients with hypertension were divided into two groups. Obese patients had a statistically significant increase in office blood pressure, FSI, the ratio of TG and LDL-C to HDL-C, a more significant higher average levels of glucose, TG and ALT levels, as well as impaired hepatic blood flow according to ultrasound.ConclusionIndicators of FSI, ALT/AST ratio, ratio of TG and LDL-С to HDL-C as well as assessment of hepatic blood flow indicators can be used for early diagnosis of nonalcoholic fatty liver disease, as they predict liver steatosis.

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