• Br J Anaesth · Aug 2023

    Editorial

    Early exposure to general anaesthesia and increasing trends in developmental behavioural impairments: is there a link?

    • Vesna Jevtovic-Todorovic and Nemanja Useinovic.
    • Department of Anaesthesiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: vesna.jevtovic-todorovic@cuanschutz.edu.
    • Br J Anaesth. 2023 Aug 1; 131 (2): 208211208-211.

    AbstractOver the past two decades there has been an increase in reports of attention deficit-hyperactivity disorder and perhaps autism spectrum disorder that appear to coincide with a substantial number of general anaesthesia interventions during early stages of human brain development. Is there a link between anaesthesia exposure and neurocognitive effects considering the growing body of evidence in numerous animal species, including humans, that suggests long-lasting socio-affective behavioural impairments after early exposure to general anaesthesia? Could routinely used general anaesthetics contribute as environmental toxins? Here we present the case that this notion is worthy of further consideration.Copyright © 2023 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

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