• Alison N Huffstetler, Joseph Fraiman, Shannon Brownlee, Michael A Stoto, and Kenneth W Lin.
• From Virginia Commonwealth University, Richmond, VA (ANH); Thibodaux Regional Medical Center, Department of Emergency Medicine, Thibodaux, LA (JF); Lown Institute, Boston, MA (SB); Georgetown University, Department of Health Systems Administration, Washington, DC (MAS); Georgetown University School of Medicine, Department of Family Medicine, Washington, DC (KWL). alison.huffstetler@vcuhealth.org.
• J Am Board Fam Med. 2023 May 8; 36 (3): 493500493-500.

ObjectiveThis study aims to comprehensively assess the direct, severe harms of screening colonoscopy in the United States. Whereas other investigators have completed systematic reviews estimating the harms of all types of colonoscopy, this analysis focuses on screening colonoscopies that had adequate follow up to avoid undercounting delayed harms.Data SourcesPubMed and Embase were queried for relevant studies on screening colonoscopy harms published between January 1, 2002, and April 1, 2022.Study SelectionEnglish-language studies of screening colonoscopy for average risk patients were included. Studies must have followed patients for adequate time post procedure, defined as 30 days after colonoscopy.Main OutcomesThe primary outcome was the number of severe bleeding events and gastrointestinal (GI) perforations within 30 days of screening colonoscopy.ResultsA total of 1951 studies were reviewed for inclusion; 94 were reviewed in full text. Of those reviewed in full, 6 studies, including a total of 467,139 colonoscopies, met our inclusion criteria and were included in our analysis of harms related to screening colonoscopies. The rate of severe bleeding ranged credibly from 16.4 to 36.18 per 10,000 colonoscopies; the rate of perforation ranged credibly from 7.62 to 8.50 per 10,000 colonoscopies.ConclusionsThis study is the first to estimate direct harms from screening colonoscopy, including harms that occur up to 30 days after the procedure. The risk of harm subsequent to screening colonoscopy is higher than previously reported and should be discussed with patients when engaging in shared decision making.© Copyright by the American Board of Family Medicine.

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