• Internal medicine · Jan 2024

    Case Reports

    A Case of Hepatocellular Carcinoma Showing Tumor Shrinkage due to an Abscopal Effect.

    • Ryo Yano, Masashi Hirooka, Makoto Morita, Yuki Okazaki, Yoshiko Nakamura, Yusuke Imai, Takao Watanabe, Yohei Koizumi, Osamu Yoshida, Yoshio Tokumoto, Masanori Abe, and Yoichi Hiasa.
    • Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan.
    • Intern. Med. 2024 Jan 15; 63 (2): 241246241-246.

    AbstractWe herein report a 63-year-old man who presented with left lower jaw pain and was diagnosed with hepatocellular carcinoma with bone metastases post-examination. All tumors grew after immunotherapy with atezolizumab and bevacizumab, and his jaw pain worsened. After palliative radiation therapy, however, the tumors shrank markedly, with no recurrence seen after stopping immunotherapy. To our knowledge, this is the first case in which a radiotherapy- and immunotherapy-mediated abscopal effect facilitated tumor shrinkage and immunotherapy discontinuation.

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