• Sao Paulo Med J · Jan 2023

    Observational Study

    Cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia: did we discard this tool too soon?

    • Mariana Dalbo Contrera Toro, Erica Ortiz, Fernando Augusto Lima Marson, Laíza Mohana Pinheiro, Adyléia Aparecida Dalbo Contrera Toro, José Dirceu Ribeiro, and Eulália Sakano.
    • MD, MSc. PhD Student, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.
    • Sao Paulo Med J. 2023 Jan 1; 141 (6): e2022508e2022508.

    BackgroundPrimary ciliary dyskinesia (PCD) is a rare and heterogeneous disease that is difficult to diagnose and requires complex and expensive diagnostic tools. The saccharin transit time test is a simple and inexpensive tool that may assist in screening patients with PCD.ObjectivesThis study aimed to compare changes in the electron microscopy findings with clinical variables and saccharin tests in individuals diagnosed with clinical PCD (cPCD) and a control group.Design And SettingAn observational cross-sectional study was conducted in an otorhinolaryngology outpatient clinic from August 2012 to April 2021.MethodPatients with cPCD underwent clinical screening questionnaires, nasal endoscopy, the saccharin transit time test, and nasal biopsy for transmission electron microscopy.ResultsThirty-four patients with cPCD were evaluated. The most prevalent clinical comorbidities in the cPCD group were recurrent pneumonia, bronchiectasis, and chronic rhinosinusitis. Electron microscopy confirmed the clinical diagnosis of PCD in 16 of the 34 (47.1%) patients.ConclusionThe saccharin test could assist in screening patients with PCD due to its association with clinical alterations related to PCD.

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