• Beatriz Nienkotter, Marcelo Vier Gambetta, Franciani Rodrigues da Rocha, Erick Dieter Medeiros, Israel Schweitzer, Fernanda Prado, and Paulo Sergio da Silva Deschamps.
• Centro Universitário para o Desenvolvimento do Alto Vale do Itajaí, Núcleo de Pesquisa em Ciências Médicas: Investigações em Saúde, Faculdade de Medicina - Rio do Sul (SC), Brazil.
• Rev Assoc Med Bras (1992). 2023 Jan 1; 69 (5): e20220917e20220917.

ObjectiveThis study aimed to analyze the clinical-epidemiological profile, possible risk predictors, and outcomes of patients with coronavirus disease 2019 admitted to the ward of a tertiary care hospital in southern Brazil. Specifically, we describe the demographic characteristics, comorbidities, baseline laboratory findings, clinical course, and survival of these patients.MethodsThis is an observational, retrospective cohort study, performed from January to March 2022, on medical records of patients hospitalized between April 2020 and December 2021 in the coronavirus disease 2019 ward of a tertiary hospital in southern Brazil.ResultsData from 502 hospitalized patients were analyzed, of which 60.2% were male, with a median age of 56 years and 31.7% were over 65 years old. The main symptoms presented were dyspnea/respiratory discomfort (69.9%) and cough (63.1%). The most common comorbidities were obesity, systemic arterial hypertension, and diabetes mellitus. A proportion of 55.8% of 493 patients had PaO2/FiO2<300 mmHg in the first examination performed after admission and 46.0% had a neutrophil/lymphocyte ratio>6.8. Oxygen therapy by Venturi mask or mask with reservoir was used in 34.7% of the patients, and non-invasive ventilation was used in 10.0% of the patients. The majority of the patients (98.4%) used corticosteroids, and the outcome of 82.5% of the hospitalized patients was home discharge.ConclusionAfter analyzing the clinical and epidemiological profile, it can be concluded that age greater than 65 years and pulmonary involvement >50% are predictors of a worse prognosis for coronavirus disease 2019, as is the need for high-flow oxygen therapy. Corticotherapy, however, proved to be beneficial in the treatment of the disease.

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