• Oscar Krol, Kimberly McFarland, Stephane Owusu-Sarpong, Navraj Sagoo, Tyler Williamson, Rachel Joujon-Roche, Peter Tretiakov, Bailey Imbo, Pooja Dave, Jamshaid Mir, Jordan Lebovic, Oluwatobi O Onafowokan, Andrew J Schoenfeld, Rafael De la Garza Ramos, Muhammad Burhan Janjua, Daniel M Sciubba, Bassel G Diebo, Shaleen Vira, Justin S Smith, Virginie Lafage, Renaud Lafage, and Peter G Passias.
• Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY.
• Spine. 2023 Oct 1; 48 (19): 134813531348-1353.

BackgroundPatients undergoing surgery for adult spinal deformity (ASD) are often elderly, frail, and at elevated risk of adverse events perioperatively, with proximal junctional failure (PJF) occurring relatively frequently. Currently, the specific role of frailty in potentiating this outcome is poorly defined.PurposeTo determine if the benefits of optimal realignment in ASD, with respect to the development of PJF, can be offset by increasing frailty.Study DesignRetrospective cohort.Materials And MethodsOperative ASD patients (scoliosis >20°, SVA>5 cm, pelvic tilt>25°, or TK>60°) fused to the pelvis or below with available baseline and 2-year (2Y) radiographic and HRQL data were included. The Miller Frailty Index (FI) was used to stratify patients into 2 categories: Not Frail (FI <3) and Frail (>3). Proximal Junctional Failure (PJF) was defined using the Lafage criteria. "Matched" and "unmatched" refers to ideal age-adjusted alignment postoperatively. Multivariable regression determined the impact of frailty on the development of PJF.ResultsTwo hundred eighty-four ASD patients met inclusion criteria [62.2yrs±9.9, 81%F, BMI: 27.5 kg/m 2 ±5.3, ASD-FI: 3.4±1.5, Charlson Comorbidity Index (CCI): 1.7±1.6]. Forty-three percent of patients were characterized as Not Frail (NF) and 57% were characterized as Frail (F). PJF development was lower in the NF group compared with the F group (7% vs . 18%; P =0.002). F patients had 3.2 × higher risk of PJF development compared to NF patients (OR: 3.2, 95% CI: 1.3-7.3, P =0.009). Controlling for baseline factors, F unmatched patients had a higher degree of PJF (OR: 1.4, 95% CI:1.02-1.8, P =0.03); however, with prophylaxis, there was no increased risk. Adjusted analysis shows F patients, when matched postoperatively in PI-LL, had no significantly higher risk of PJF.ConclusionsAn increasingly frail state is significantly associated with the development of PJF after corrective surgery for ASD. Optimal realignment may mitigate the impact of frailty on eventual PJF. Prophylaxis should be considered in frail patients who do not reach ideal alignment goals.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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