• Andrea Lavinio, John Andrzejowski, Ileana Antonopoulou, Jonathan Coles, Pierce Geoghegan, Kyle Gibson, Sandeep Gudibande, Carmen Lopez-Soto, Randeep Mullhi, Priya Nair, Vijai P Pauliah, Aoife Quinn, Frank Rasulo, Andrew Ratcliffe, Ugan Reddy, Jonathan Rhodes, Chiara Robba, Matthew Wiles, and Ashleigh Williams.
• Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. Electronic address: andrea.lavinio1@nhs.net.
• Br J Anaesth. 2023 Aug 1; 131 (2): 294301294-301.

BackgroundThere is a lack of consistent, evidence-based guidelines for the management of patients with fever after brain injury. The aim was to update previously published consensus recommendations on targeted temperature management after intracerebral haemorrhage, aneurysmal subarachnoid haemorrhage, and acute ischaemic stroke in patients who require admission to critical care.MethodsA modified Delphi consensus, the Neuroprotective Therapy Consensus Review (NTCR), included 19 international neuro-intensive care experts with a subspecialty interest in the acute management of intracerebral haemorrhage, aneurysmal subarachnoid haemorrhage, and acute ischaemic stroke. An online, anonymised survey was completed ahead of the meeting before the group came together to consolidate consensus and finalise recommendations on targeted temperature management. A threshold of ≥80% for consensus was set for all statements.ResultsRecommendations were formulated based on existing evidence, literature review, and consensus. After intracerebral haemorrhage, aneurysmal subarachnoid haemorrhage, and acute ischaemic stroke in patients who require critical care admission, core temperature should ideally be monitored continuously and maintained between 36.0°C and 37.5°C using automated feedback-controlled devices, where possible. Targeted temperature management should be commenced within 1 h of first fever identification with appropriate diagnosis and treatment of infection, maintained for as long as the brain remains at risk of secondary injury, and rewarming should be controlled. Shivering should be monitored and managed to limit risk of secondary injury. Following a single protocol for targeted temperature management across intracerebral haemorrhage, aneurysmal subarachnoid haemorrhage, and acute ischaemic stroke is desirable.ConclusionsBased on a modified Delphi expert consensus process, these guidelines aim to improve the quality of targeted temperature management for patients after intracerebral haemorrhage, aneurysmal subarachnoid haemorrhage, and acute ischaemic stroke in critical care, highlighting the need for further research to improve clinical guidelines in this setting.Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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