• Internal medicine · Jan 2024

    Case Reports

    An Adult Case of Idiopathic Pulmonary Hemosiderosis Associated with Pulmonary Fibrosis and Emphysematous Change.

    • Masato Kono, Yuiko Oshima, Megumi Katsumata, Ryutaro Hirama, Kenichiro Takeda, Yasutaka Mochizuka, Akari Tsutsumi, Hideki Miwa, Yoshihiro Miki, Dai Hashimoto, Yoshiro Otsuki, Takafumi Suda, and Hidenori Nakamura.
    • Department of Respiratory Medicine, Seirei Hamamatsu General Hospital, Japan.
    • Intern. Med. 2024 Jan 1; 63 (1): 119124119-124.

    AbstractA 48-year-old woman was admitted to our hospital with acute respiratory failure. Chest computed tomography showed ground-glass opacity and patchy emphysematous lesions in both lungs. Corticosteroid therapy was effective; however, the disease worsened with the tapering of corticosteroids. Bronchoalveolar lavage revealed hemosiderin-laden macrophages, and video-assisted thoracic surgery showed diffuse interstitial fibrosis with diffuse alveolar hemorrhage (DAH). There was no evidence of vasculitis nor autoimmune diseases. This patient was diagnosed with idiopathic pulmonary hemosiderosis (IPH) that progressed to end-stage pulmonary fibrosis despite treatment. Autopsy demonstrated DAH with pulmonary fibrosis and emphysematous change, suggesting IPH-related pulmonary lesions.

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