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- Noriyuki Kounoue, Hideyo Oguchi, Tetuo Mikami, Yutaka Yamaguchi, Akinori Hashiguchi, Hidenari Nagai, Kaori Watanabe, Satoshi Furukawa, Kana Hisamatsu, and Ken Sakai.
- Department of Nephrology, Toho University Faculty of Medicine, Japan.
- Intern. Med. 2024 Jan 1; 63 (1): 101106101-106.
AbstractA man who was an inactive hepatitis B virus (HBV) carrier with positive hepatitis B surface antigen (HBs antigen) and undetectable HBV-DNA under anti-viral treatment developed nephrotic syndrome at 52 years old, and a renal biopsy revealed advanced membranous nephropathy (MN) with focal cellular crescents, interstitial hemorrhaging, and peritubular capillaritis. Immunofluorescence studies demonstrated granular IgG deposition and HBs antigen-positivity along the capillaries. Glomeruli were negative for phospholipase A2 receptor 1. There were no clinical findings of systemic vasculitis. We considered MN combined with small-vessel vasculitis due to HBV infection. These results suggest that HBV-related kidney disease should be considered even in patients with an inactive HBV carrier status under treatment.
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