• Yavuz Samanci, M Orbay Askeroglu, Ahmed M Nabeel, Wael A Reda, Sameh R Tawadros, Khaled Abdelkarim, El-ShehabyAmr M NAMNGamma Knife Center Cairo, Nasser Institute Hospital, Cairo , Egypt.Department of Neurosurgery, Ain Shams University, Cairo , Egypt., Reem M Emad, Andrew Legarreta, David Fernandes Cabral, Sharath Anand, Ajay Niranjan, L Dade Lunsford, Manjul Tripathi, Narendra Kumar, Roman Liščák, Jaromir May, Cheng-Chia Lee, Huai-Che Yang, Martínez MorenoNuriaNRadiosurgery Unit, Hospital Ruber Internacional, Madrid , Spain., Martínez ÁlvarezRobertoRRadiosurgery Unit, Hospital Ruber Internacional, Madrid , Spain., Keiss Douri, David Mathieu, Stylianos Pikis, Georgios Mantziaris, Jason P Sheehan, Kenneth Bernstein, Douglas Kondziolka, and Selcuk Peker.
• Department of Neurosurgery, Koc University School of Medicine, Istanbul , Turkey.
• Neurosurgery. 2023 Nov 1; 93 (5): 106610741066-1074.

Background And ObjectivesMeningiomas in children are uncommon, with distinct characteristics that set them apart from their adult counterparts. The existing evidence for stereotactic radiosurgery (SRS) in this patient population is limited to only case series. The objective of this study was to evaluate the safety and efficacy of SRS in managing pediatric meningiomas.MethodsChildren and adolescents who had been treated for meningioma with single-fraction SRS were included in this retrospective, multicenter study. The assessment included local tumor control, any complications related to the tumor or SRS, and the emergence of new neurological deficits after SRS.ResultsThe cohort included 57 patients (male-to-female ratio 1.6:1) with a mean age of 14.4 years who were managed with single-fraction SRS for 78 meningiomas. The median radiological and clinical follow-up periods were 69 months (range, 6-268) and 71 months (range, 6-268), respectively. At the last follow-up, tumor control (tumor stability and regression) was achieved in 69 (85.9%) tumors. Post-SRS, new neurological deficits occurred in 2 (3.5%) patients. Adverse radiation effects occurred in 5 (8.8%) patients. A de novo aneurysm was observed in a patient 69 months after SRS.ConclusionSRS seems to be a safe and effective up-front or adjuvant treatment option for surgically inaccessible, recurrent, or residual pediatric meningiomas.Copyright © Congress of Neurological Surgeons 2023. All rights reserved.

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