• World Neurosurg · Aug 2023

    Differences in Time to Achieve Minimum Clinically Important Difference between Patients Undergoing Anterior Cervical Discectomy and Fusion and Cervical Disc Replacement.

    • Vincent P Federico, James W Nie, Timothy J Hartman, Eileen Zheng, Omolabake O Oyetayo, Keith R MacGregor, Dustin H Massel, Arash J Sayari, and Kern Singh.
    • Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.
    • World Neurosurg. 2023 Aug 1; 176: e337e344e337-e344.

    ObjectiveTo compare patients undergoing anterior cervical discectomy and fusion (ACDF) versus cervical disc replacement (CDR) for time to minimum clinically important difference (MCID) achievement and predictors of delayed MCID achievement for the patient-reported outcomes (PROs), Patient-Reported Outcomes Measurement Information System Physical Function, Neck Disability Index, Visual Analog Scale (VAS) neck, and VAS arm.MethodsPROs of patients undergoing ACDF or CDR were collected preoperatively and postoperatively at 6-week/12-week/6-month/1-year/2-year periods. MCID achievement was calculated through comparison of changes in Patient-Reported Outcomes Measurement to previously established values in literature. Time to MCID achievement and predictors for delayed MCID achievement were determined through Kaplan-Meier survival analysis and multivariable Cox regression, respectively.ResultsOne hundred ninety-seven patients were identified, with 118 and 79 undergoing ACDF and CDR, respectively. Kaplan-Meier survival analysis demonstrated faster time to achieve MCID for CDR patients in Patient-Reported Outcomes Measurement Information System Physical Function (P = 0.006). Early predictors of MCID achievement through Cox regression were CDR procedure, Asian ethnicity, elevated preoperative PROs of VAS neck and VAS arm (hazard ratio, 1.16-7.28). Workers' compensation was a late predictor of MCID achievement (hazard ratio, 0.15).ConclusionsMost patients achieved MCID in physical function, disability, and back pain outcomes within 2 years of surgery. Patients undergoing CDR achieved MCID faster in physical function. Early predictors of MCID achievement were CDR procedure, Asian ethnicity, and elevated preoperative PROs of pain outcomes. Workers' compensation was a late predictor. These findings may be helpful in managing patient expectations.Copyright © 2023 Elsevier Inc. All rights reserved.

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