• Itamar Poran, Amjaad Abu Mokh, Daniella Vronsky, Genady Drozdinsky, Bar Basharim, and Noa Eliakim-Raz.
• Rabin Medical Center, Beilinson Hospital, Internal Medicine E, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: itamarporan@gmail.com.
• Med Clin (Barc). 2023 Jul 21; 161 (2): 596159-61.

IntroductionInitiation of global vaccination significantly reduced the morbidity and mortality of COVID-19. During the Omicron wave, approximately 70% of the Israeli adult population was fully vaccinated, but the efficacy of the vaccine was questioned.MethodsWe conducted a retrospective cohort study of all adult patients admitted to the COVID-19 departments in Rabin Medical Center, during the Delta wave and the Omicron wave. Patients were matched in the 2 waves using the inverse probability of treatment weighting (IPTW) method and risk for mechanical ventilation and 30-day all-cause mortality was assessed.ResultsVaccination had a significant effect on 30-day mortality in the Delta and Omicron waves with adjusted OR of 0.35 (0.17-0.70) and 0.5 (0.27-0.95) respectively. Nonetheless, the rate of mechanical ventilation was similar between the groups with OR of 0.75 (0.52-1.09) and 0.64 (0.40-1.01). Vaccination status did not change the length of admission in both waves.ConclusionWe observed a decreased risk for 30-day mortality among vaccinated patients during the Delta and Omicron waves in Israel. This association, even though consistent, was of a lesser magnitude during the Omicron wave.Copyright © 2023 Elsevier España, S.L.U. All rights reserved.

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