• Clin Med (Lond) · May 2023

    Review

    Monoclonal gammopathies of renal significance.

    • Sahana Gnanasampanthan and Andreas Kousios.
    • Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK.
    • Clin Med (Lond). 2023 May 1; 23 (3): 250253250-253.

    AbstractThe term monoclonal gammopathies of renal significance (MGRS) encompasses a group of renal histopathological lesions fulfilling two criteria: (a) they are caused by nephrotoxic monoclonal immunoglobulins and (b) the monoclonal immunoglobulins are produced by small B-cell or plasma cell clones which do not meet the criteria for multiple myeloma or malignant lymphoma. Here, we provide a review of the MGRS definition and related terminology and elaborate on the diagnostic approach and treatment principles from the general physician perspective.© Royal College of Physicians 2023. All rights reserved.

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