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- Hisato Shima, Yusuke Higashiguchi, Toshio Doi, Megumi Harada, Takuya Okamoto, Tomoko Inoue, Manabu Tashiro, Kazuyoshi Okada, and Jun Minakuchi.
- Department of Kidney Disease, Kawashima Hospital, Japan.
- Intern. Med. 2024 Feb 1; 63 (3): 433438433-438.
AbstractWe herein report three cases of steroid-resistant nephrotic syndrome successfully treated with low-density lipoprotein apheresis (LDL-A). All patients were treated with a combination of steroids, cyclosporine, and LDL-A. In all cases, the serum concentrations of LDL, total and high-density lipoprotein cholesterol, and triglycerides were significantly lowered following LDL-A administration. Furthermore, the estimated LDL receptor activity increased, while both serum LDL and total cholesterol levels decreased, suggesting that LDL-A increases LDL receptor activity by driving changes in serum cholesterol concentration. This case series suggests that LDL-A increases LDL receptor activity, which may improve the intracellular uptake of cyclosporine.
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