• Internal medicine · Jan 2024

    Case Reports

    Sarcoidosis Associated with Enlarged Mediastinal Lymph Nodes with the Detection of Streptococcus gordonii and Cutibacterium acnes Using a Clone Library Method: A Case Report.

    • Kentaro Akata, Kei Yamasaki, Kazuki Nemoto, Hiroaki Ikegami, Takako Kawaguchi, Shingo Noguchi, Toshinori Kawanami, Kazumasa Fukuda, Hiroshi Mukae, and Kazuhiro Yatera.
    • Division of Infection Control and Prevention, University of Occupational and Environmental Health, Japan.
    • Intern. Med. 2024 Jan 15; 63 (2): 299304299-304.

    AbstractA 77-year-old Japanese woman with mediastinal lymphadenopathy and uveitis was diagnosed with sarcoidosis. The bacterial flora in biopsied samples from mediastinal lymph nodes was analyzed using a clone library method with Sanger sequencing of the 16S rRNA gene, and Streptococcus gordonii (52 of 71 clones) and Cutibacterium acnes (19 of 71 clones) were detected. No previous study has conducted a bacterial floral analysis using the Sanger method for the mediastinal lymph node in sarcoidosis, making this case report the first to document the presence of S. gordonii and C. acnes in the mediastinal lymph node of a patient with sarcoidosis.

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