• Internal medicine · Jan 2024

    Review Case Reports

    Rare Coexistence of Aldosterone-producing Adrenocortical Adenoma Confirmed by an Immunohistochemical Analysis of Steroidogenic Enzymes with Adrenal Ectopic Thyroid Tissue: A Case Report and Literature Review.

    • Yohsuke Ohkubo, Masanori Yamazaki, Yasuho Shimada, Satoshi Kubota, Shohei Takayama, Ako Oiwa, Yuta Yamazaki, Hironobu Sasano, and Mitsuhisa Komatsu.
    • Department of Diabetes, Endocrinology and Metabolism, Division of Internal Medicine, Shinshu University School of Medicine, Japan.
    • Intern. Med. 2024 Jan 15; 63 (2): 259264259-264.

    AbstractA 56-year-old man presented with a history of hypertension; clinically, the patient had primary aldosteronism (PA) and a 4-cm left adrenal tumor. The left adrenal glands, resected by adrenalectomy, also contained ectopic thyroid tissue (ETT). An immunohistochemical analysis of steroid-converting enzymes revealed an aldosterone-producing adenoma (APA). Among 19 previously reported cases of adrenal ETT, 4 had adrenal hormonal abnormalities, all of which were PA. This is the first case of adrenal ETT coexisting with APA, confirmed by steroid-converting enzyme expression. Further analyses using cumulative case data are required to clarify the correlation between adrenal ETT and APA.

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