• Internal medicine · Jan 2024

    Case Reports

    A Case of Nivolumab Therapy in Lung Cancer Associated with IgG4-related Disease.

    • Mari Aso, Hiroki Suzuki, Takafumi Aizawa, Sachie Nawa, Hiroki Ota, Hitomi Nogawa, and Toshihiko Hino.
    • Department of Pulmonary Medicine, Yamagata Prefectural Central Hospital, Japan.
    • Intern. Med. 2024 Jan 15; 63 (2): 283287283-287.

    AbstractA 75-year-old man with severe bilateral pleural thickening and dense soft tissue masses surrounding the abdominal aorta on computed tomography was diagnosed with IgG4-related disease (IgG4-RD) as a complication of lung cancer. He was started on nivolumab as second-line therapy along with low-dose prednisolone. Nivolumab was administered for 15 months until disease progression, during which time IgG4-RD did not relapse, and no problematic immune-related adverse events occurred. These results suggest that anti-programmed cell death protein-1 antibody may be used safely in lung cancer associated with IgG4-RD concomitantly with low-dose steroids.

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