• Alexander Stoker, Anne Hicks, WrightMary CooterMCDepartment of Anesthesiology, Biostatistics, Duke University Medical Center, Durham, NC., Azfar Ali, Jacob Klapper, Jessica Poisson, Lorenzo Zaffiri, Dongfeng Chen, Matthew Hartwig, Kamrouz Ghadimi, Ian Welsby, and Brandi Bottiger.
• Department of Anesthesiology, Cardiothoracic Anesthesiology Division, Duke University Medical Center, Durham, NC.
• J. Cardiothorac. Vasc. Anesth. 2023 Sep 1; 37 (9): 160916171609-1617.

ObjectivesThe development of new human leukocyte antigens (HLAs) and donor-specific antibodies (DSAs) in patients are associated with worse outcomes following lung transplantation. The authors aimed to examine the relationship between blood product transfusion in the first 72 hours after lung transplantation and the development of HLA antibodies, including DSAs.DesignA retrospective observational study.SettingAt a single academic tertiary center.ParticipantsAdult lung transplant recipients who underwent transplantation between September 2014 and June 2019.InterventionsNone.Measurements And Main ResultsA total of 380 patients were included in this study, and 87 (23%) developed de novo donor-specific antibodies in the first year after transplantation. Eighty-five patients (22%) developed new HLA antibodies that were not donor-specific, and 208 patients (55%) did not develop new HLA antibodies in the first year after transplantation. Factors associated with increased HLA and DSA development included donor pulmonary infection, non-infectious indication for transplant, increased recipient body mass index, and a preoperative calculated panel reactive antibody value above 0. Multivariate analysis identified platelet transfusion associated with an increased risk of de novo HLA antibody development compared to the negative group (odds ratio [OR; 95% CI] 1.18 [1.02-1.36]; p = 0.025). Cryoprecipitate transfusion was associated with de novo DSA development compared to the negative group (OR [95% CI] 2.21 [1.32-3.69] for 1 v 0 units; p = 0.002).ConclusionsIncreased perioperative transfusion of platelets and cryoprecipitate are associated with de novo HLA and DSA development, respectively, in lung transplant recipients during the first year after transplantation.Copyright © 2023 Elsevier Inc. All rights reserved.

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