• Esther B E Becker, Luigi Zuliani, Rosemary Pettingill, Bethan Lang, Patrick Waters, Anna Dulneva, Frank Sobott, Mark Wardle, Francesc Graus, Luis Bataller, Neil P Robertson, and Angela Vincent.
• Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford University, Oxford, UK.
• J. Neurol. Neurosurg. Psychiatr. 2012 Apr 1; 83 (4): 437440437-40.

BackgroundRelatively few studies have searched for potentially pathogenic antibodies in non-paraneoplastic patients with cerebellar ataxia.Methods And ResultsWe first screened sera from 52 idiopathic ataxia patients for binding of serum IgG antibodies to cerebellar neurons. One strong-binding serum was selected for immunoprecipitation and mass spectrometry, which resulted in the identification of contactin-associated protein 2 (CASPR2) as a major antigen. CASPR2 antibodies were then found by a cell-based assay in 9/88 (10%) ataxia patients, compared to 3/144 (2%) multiple sclerosis or dementia controls (p=0.011). CASPR2 is strongly expressed in the cerebellum, only partly in association with voltage-gated potassium channels.ConclusionsProspective studies are now needed to see whether identification of CASPR2 antibodies has relevance for the diagnosis and treatment of idiopathic cerebellar ataxia.

16 keywords...

hide…