• Hermann Toplak, Aikaterini Bilitou, Hannes Alber, Johann Auer, Martin Clodi, Christoph Ebenbichler, Evelyn Fließer-Görzer, Carmen Gelsinger, Ursula Hanusch, Bernhard Ludvik, Thomas Maca, Andreas Schober, Reinhard Sock, Walter S Speidl, Thomas M Stulnig, Raimund Weitgasser, Andreas Zirlik, Marina Koch, Sebastian Wienerroither, Sorrel E Wolowacz, Françoise Diamand, and Alberico L Catapano.
• Department of Endocrinology and Diabetes, Clinic for Diabetology, Department of Internal Medicine, Medical University Graz, Graz, Austria.
• Wien. Klin. Wochenschr. 2023 Jul 1; 135 (13-14): 364374364-374.

ObjectiveThe low-density lipoprotein cholesterol goals in the 2019 European Society of Cardiology/European Atherosclerosis Society dyslipidaemia guidelines necessitate greater use of combination therapies. We describe a real-world cohort of patients in Austria and simulate the addition of oral bempedoic acid and ezetimibe to estimate the proportion of patients reaching goals.MethodsPatients at high or very high cardiovascular risk on lipid-lowering treatments (excluding proprotein convertase subtilisin/kexin type 9 inhibitors) from the Austrian cohort of the observational SANTORINI study were included using specific criteria. For patients not at their risk-based goals at baseline, addition of ezetimibe (if not already received) and subsequently bempedoic acid was simulated using a Monte Carlo simulation.ResultsA cohort of patients (N = 144) with a mean low-density lipoprotein cholesterol of 76.4 mg/dL, with 94% (n = 135) on statins and 24% (n = 35) on ezetimibe monotherapy or in combination, were used in the simulation. Only 36% of patients were at goal (n = 52). Sequential simulation of ezetimibe (where applicable) and bempedoic acid increased the proportion of patients at goal to 69% (n = 100), with a decrease in the mean low-density lipoprotein cholesterol from 76.4 mg/dL at baseline to 57.7 mg/dL overall.ConclusionsThe SANTORINI real-world data in Austria suggest that a proportion of high and very high-risk patients remain below the guideline-recommended low-density lipoprotein cholesterol goals. Optimising use of oral ezetimibe and bempedoic acid after statins in the lipid-lowering pathway could result in substantially more patients attaining low-density lipoprotein cholesterol goals, likely with additional health benefits.© 2023. The Author(s).

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