• J. Korean Med. Sci. · Jun 2023

    Case Reports

    Within-Host Evolution of SARS-CoV-2 in a B-Cell Depleted Patient With Successful Treatment.

    • Yae Jee Baek, Gemma Park, Jun Yong Choi, Eun Jin Kim, Bryan Inho Kim, Jin Gwack, and Ji Ye Jung.
    • Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
    • J. Korean Med. Sci. 2023 Jun 5; 38 (22): e175e175.

    AbstractProlonged viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised host is a challenge as the treatment and infection control for chronic coronavirus disease 2019 infection is not well established and there is a potential risk of new variants emerging. A 48-year-old woman who underwent chemotherapy, including rituximab and steroid, had reactivation of SARS-CoV-2 68 days after the virus was first detected. She successfully recovered after receiving convalescent plasma and intravenous immunoglobulin. Genomic analysis demonstrated that viruses collected from the nasopharyngeal specimens at day 0 and day 68 had 18 different nucleotide mutations, implying within-host evolution after in-depth epidemiologic investigation.© 2023 The Korean Academy of Medical Sciences.

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