• Siavash Zamirpour, Yue Xuan, Zhongjie Wang, Axel Gomez, Joseph Leach, Dimitrios Mitsouras, David A Saloner, Julius M Guccione, Liang Ge, and Elaine E Tseng.
• Division of Adult Cardiothoracic Surgery, Department of Surgery, University of California San Francisco and San Francisco Veterans Affairs Health Care System, San Francisco, Calif; Joint Medical Program, School of Public Health, University of California Berkeley, Berkeley, Calif, and School of Medicine, University of California, San Francisco, San Francisco, Calif.
• J. Thorac. Cardiovasc. Surg. 2023 Dec 1; 166 (6): 15831593.e21583-1593.e2.

BackgroundIn ascending thoracic aortic aneurysm risk stratification, aortic area/height ratio is a reasonable alternative to maximum diameter. Biomechanically, aortic dissection may be initiated by wall stress exceeding wall strength. Our objective was to evaluate the association between aortic area/height and peak aneurysm wall stresses in relation to valve morphology and 3-year all-cause mortality.MethodsFinite element analysis was performed on 270 ascending thoracic aortic aneurysms (46 associated with bicuspid and 224 with tricuspid aortic valves) in veterans. Three-dimensional aneurysm geometries were reconstructed from computed tomography and models developed accounting for prestress geometries. Fiber-embedded hyperelastic material model was applied to obtain aneurysm wall stresses during systole. Correlations of aortic area/height ratio and peak wall stresses were compared across valve types. Area/height ratio was evaluated across peak wall stress thresholds obtained from proportional hazards models of 3-year all-cause mortality, with aortic repair treated as a competing risk.ResultsAortic area/height 10 cm2/m or greater coincided with 23/34 (68%) 5.0 to 5.4 cm and 20/24 (83%) 5.5 cm or greater aneurysms. Area/height correlated weakly with peak aneurysm stresses: for tricuspid valves, r = 0.22 circumferentially and r = 0.24 longitudinally; and for bicuspid valves, r = 0.42 circumferentially and r = 0.14 longitudinally. Age and peak longitudinal stress, but not area/height, were independent predictors of all-cause mortality (age: hazard ratio, 2.20 per 9-year increase, P = .013; peak longitudinal stress: hazard ratio, 1.78 per 73-kPa increase, P = .035).ConclusionsArea/height was more predictive of high circumferential stresses in bicuspid than tricuspid valve aneurysms, but similarly less predictive of high longitudinal stresses in both valve types. Peak longitudinal stress, not area/height, independently predicted all-cause mortality. VIDEO ABSTRACT.Published by Elsevier Inc.

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