• Medicina clinica · Aug 2023

    Role of statins in clinical evolution of octogenarian patients admitted due to COVID-19.

    • Carla Jiménez Martínez, Victoria Espejo Bares, Verónica Artiaga de la Barrera, Cecilia Marco Quirós, Elia Pérez Fernández, Maria Luz Martínez Mas, Javier Botas Rodríguez, and en representación del grupo de estudio.
    • Servicio de Cardiología, Hospital Universitario Fundación Alcorcón, Madrid, España. Electronic address: carlajimar@gmail.com.
    • Med Clin (Barc). 2023 Aug 25; 161 (4): 147153147-153.

    Introduction And Objectivescoronavirus disease 2019 (COVID-19) causes high mortality in elderly patients. Some studies have shown a benefit of statin treatment in the evolution of this disease. Since there are no similar publications in this population group, the aim of this study is to analyze in-hospital mortality in relation to preadmission treatment with statins in an exclusively elderly population of octogenarian patients.Materials And MethodsA single-center retrospective cohort study was performed including a total of 258 patients ≥80 years with hospital admission for confirmed COVID-19 between March 1 and May 31, 2020. They were divided into two groups: taking statins prior to admission (n=129) or not (n=129).ResultsIn-hospital mortality due to COVID-19 in patients ≥80 years (86.13±4.40) during the first wave was 35.7% (95% CI: 30.1-41.7%). Mortality in patients previously taking statins was 25.6% while in those not taking statins was 45.7%. Female sex (RR 0.62 [0.44-0.89]; p=0.008), diabetes (RR 0.61 [0.41-0.92]; p=0.017) and pre-admission treatment with statins (RR 0.58 95% CI [0.41-0.83]; p=0.003) were associated with lower in-hospital mortality. Severe lung involvement was associated with increased in-hospital mortality (RR 1.45 95% CI [1.04-2.03]; p=0.028). Hypertension, obesity, age, cardiovascular disease and a higher Charlson index did not, however, show influence on in-hospital mortality.ConclusionsIn octogenarian patients treated with statins prior to admission for COVID-19 in the first wave, lower in-hospital mortality was observed.Copyright © 2023 Elsevier España, S.L.U. All rights reserved.

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