• Med Glas (Zenica) · Aug 2023

    In vitro effectiveness of the avocado peel extract (Persea americana Mill) as an antifungal against Trichophyton rubrum, the cause of dermatophytosis.

    • Ira Armayanti, Meidina K Wardani, and Ariyati Yosi.
    • Department of Dermatology and Venereology, Faculty of Medicine Universitas Sumatera Utara, Medan, Indonesia.
    • Med Glas (Zenica). 2023 Aug 1; 20 (2).

    AbstractAim To determine the effectiveness of avocado peel extract (Persea americana Mill) as an antifungal against T. rubrum, which causes dermatophytosis. Methods In vitro laboratory experimental study using a post-testonly control group design analysed active compounds of avocado peel and continued with the antifungal activity test. In each group divided according to the concentration of 0% (negative control), 12.5%, 25%, 37.5%, 50%, 62.5%, 75%, and positive control (2% ketoconazole) antifungal activity test was carried out using the fungus T. rubrum ATCC 28188 for five repetitions. Results The avocado peel extract contained phenolic compounds, flavonoids, tannins, saponins, alkaloids, terpenoids, and glycosides. Antifungal activity test showed a significant difference with the highest mean inhibition zone diameter of T. rubrum, which was demonstrated at a concentration of 75%. Conclusion Avocado peel extract is useful to inhibit growth of Trichophyton rubrum in dose dependent.Copyright© by the Medical Assotiation of Zenica-Doboj Canton.

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