• Internal medicine · Sep 2023

    Case Reports

    Successful Use of Granulocyte and Monocyte Adsorptive Apheresis in a Patient with Post-COVID-19 Multisystem Inflammatory Syndrome in Adults.

    • Shuzo Kaneko, Tsuyoshi Zen, Susumu Banjoya, Toshiaki Nuki, Ainori Hoshimoto, Makiko Harano, Sou Hagiwara, Eri Imai, and Yusuke Tsukamoto.
    • Department of Nephrology, Itabashi Chuo Medical Center, Japan.
    • Intern. Med. 2023 Sep 1; 62 (17): 256525692565-2569.

    AbstractMultisystem inflammatory syndrome in adults (MIS-A) is a life-threatening disease that can develop weeks after coronavirus disease 2019 (COVID-19). MIS-A symptoms include multiorgan involvement, especially gastrointestinal tract and heart involvement, and Kawasaki disease-like symptoms. We herein report a 44-year-old Japanese man with MIS-A who had contracted COVID-19 five weeks ago and went into shock after acute gastroenteritis, acute kidney injury, and Kawasaki disease-like symptoms. Methylprednisone pulse and high-dose intravenous immunoglobulin resulted in recovery of shock and his renal function, but diffuse ST-segment elevation on electrocardiography and pericardial effusion with a fever emerged after therapy. Additional granulocyte-monocyte adsorptive apheresis successfully ameliorated the cardiac involvement.

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