• Internal medicine · Jan 2023

    Case Reports

    Combined REGN-COV2 Antibody Therapy Immediately Prevented a Patient with Refractory Type 1 Autoimmune Pancreatitis from Contracting SARS-CoV-2 during the Sixth Wave in Japan.

    • Chihiro Katsuo, Kensuke Kubota, Katsushi Tanaka, Yusuke Kurita, and Atsushi Nakajima.
    • Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Japan.
    • Intern. Med. 2023 Jan 1; 62 (12): 176517701765-1770.

    AbstractA 51-year-old man who had been receiving steroid therapy for type 1 autoimmune pancreatitis (AIP) for 3 years contracted coronavirus disease 2019 (COVID-19). As he had a high-grade fever and dry cough, and because his SpO2 level had dropped below 95% in the supine position, he was considered as being at a high risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); therefore, he received combined REGN-COV2 antibody therapy. The patient's fever resolved immediately after this treatment, and he went into remission. A high cumulative steroid dose is associated with an increased susceptibility to infection. Early antibody cocktail therapy may be effective and rewarding for steroid-dependent type 1 AIP patients with a potential risk for SARS-CoV-2.

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